Codeage® Biotin Marine Collagen + Hyaluronic Acid + Vitamin C: The Complete Beauty Supplement Guide

Dai Tran, PharmD, MBA, B.S.

CEO & Lead Pharmacist, Khang Pharmacy • CA/MN/TX Licensed Pharmacist

Clinical Insights Series • APhA Immunization Certified • 10+ Years Clinical Experience

The Clinical Question

Has a combination of marine collagen peptides, hyaluronic acid, biotin, and Vitamins C and E been clinically evaluated for skin and hair outcomes — and what does the evidence actually establish for each ingredient and for the combination?

Bottom Line Up Front

A placebo-controlled human study has evaluated a combination containing collagen, hyaluronic acid, biotin, Vitamin C, and Vitamin E and reported improvements in selected skin and hair outcomes at 56 days. However, that formulation (Skin Radiance Collagen) was not Codeage® Biotin Marine Collagen — differences in ingredient sources, preparations, and doses prevent direct transfer of those clinical results to this finished product. Individual ingredient evidence is reviewed below. Vitamin C and E are included based on established biochemical rationale rather than independent beauty-outcome RCT evidence at these doses.

About This Formula

Codeage® Wild-Caught Marine Collagen with Biotin combines five principal ingredients in a single capsule: marine collagen peptides (Types 1 & 3), biotin (10,000 mcg), hyaluronic acid, Vitamin C, and Vitamin E. Each ingredient has a distinct biological rationale for skin, hair, or nail health.

What Human Studies Show

1. Combination Formula Evidence (Collagen + HA + Biotin + Vitamins C & E)

• HUMAN RCT Trehan et al., 2024 (PMID: 38495912) — Skin Radiance Collagen placebo-controlled trial: Placebo-controlled clinical trial (n=40 women aged 38–50) evaluating Skin Radiance Collagen, a supplement containing collagen, hyaluronic acid, biotin, Vitamin C, and Vitamin E — the same five principal ingredient categories as this Codeage formula. At 56 days, the SRC group showed statistically significant improvements vs. placebo in selected skin outcomes including wrinkle depth, fine lines, skin hydration, and skin texture, as well as reduced hair fall. Evidence-quality note: All five study authors were affiliated with Bright Lifecare Pvt. Ltd., the commercial entity associated with the intervention; this affiliation should be considered when interpreting results even though the paper states no conflicts of interest. SRC is a different proprietary formulation from Codeage® Biotin Marine Collagen — these results cannot be attributed to this product.

2. Marine Collagen Evidence

Since this product uses wild-caught marine collagen, the most relevant collagen evidence comes from fish-derived collagen RCTs. For a full review of marine collagen evidence, see our companion article: Codeage® Wild-Caught Marine Collagen Peptides: The Pharmacist’s Guide →

• HUMAN RCT Evans et al., 2021 (PMID: 32799362): Randomized, triple-blind, placebo-controlled trial; n=50 women aged 45–60; hydrolyzed marine collagen (Vinh Wellness Collagen) 10 g/day for 12 weeks. Significant within-group wrinkle reduction (35%); greater between-group reduction on one side of the face vs. placebo; planned age-subgroup showed cheek elasticity improvements. Supports marine collagen component; not this finished product.
• HUMAN RCT Kim et al., 2018 (PMID: 29949889): Randomized, double-blind, placebo-controlled; n=64; fish collagen peptides 1,000 mg/day for 12 weeks. Significantly greater skin hydration at weeks 6 and 12; wrinkle improvement and two of three elasticity parameters significantly better than placebo at week 12. Fish-derived collagen; not this finished product.
• HUMAN RCT Lee et al., 2024 (PMID: 38854476): Randomized, double-blind, placebo-controlled; n=85 randomized (78 completed); ages 35–60 with photo-aged skin; Pangasius fish skin collagen hydrolysate 1,000 mg/day for 12 weeks. Significant improvements in hydration, roughness, and elasticity at 6 and 12 weeks vs. placebo. Note: industry-funded study. Fish-derived collagen; not this finished product.

3. Oral Hyaluronic Acid Evidence

• HUMAN RCT PMID: 34203487 — Oral HA wrinkle and dry skin RCT: Randomized, double-blind, placebo-controlled trial; n=40; ages 35–64; oral HA 120 mg/day for 12 weeks. Significant improvements in wrinkles, stratum corneum water content, and skin elasticity vs. placebo. Specific oral HA preparation; not this finished product.
• HUMAN RCT Gao et al. (PMID: 38009035) — Larger oral HA RCT: Randomized, double-blind; n=129 women; oral HA at 100 mg/day and 200 mg/day; significant improvements in skin hydration across age groups and skin types. Additional skin tone and epidermal-thickness findings reported. Evidence-quality note: Several authors were affiliated with Bloomage Biotech Co., Ltd., a commercial HA manufacturer; this affiliation should be considered when interpreting results. Specific oral HA preparation; not this finished product.
• SYSTEMATIC REVIEW / META-ANALYSIS PMID: 40911749 — Oral HA meta-analysis: Seven RCTs included; pooled analysis found statistically significant improvements in skin hydration, elasticity, and wrinkle depth with oral HA supplementation. The authors noted limited sample sizes and heterogeneity across included trials and called for larger, more robust studies.

4. Biotin Evidence — A Deliberately Conservative Assessment

• PRELIMINARY Lipner & Scher, 2018 (PMID: 29057689) — Biotin for nail disease: Review of biotin evidence for brittle nail syndrome; reports of improved nail firmness, hardness, and thickness; authors emphasized the need for larger controlled trials. Brittle nail evidence is preliminary but more favorable than hair evidence.
• CRITICAL APPRAISAL Yelich et al., 2024 (PMID: 39148962) — Biotin for hair loss: Systematic review; only three eligible human studies identified. The highest-quality double-blind, placebo-controlled study found no significant difference in hair growth between biotin and placebo. Authors concluded that biotin use as a hair supplement is not supported by high-quality evidence. High-dose biotin supplementation for hair growth in non-deficient individuals is not established by current evidence.

5. Vitamin C and Vitamin E — Biochemical Rationale

Vitamin C is a required enzymatic cofactor for collagen cross-linking — it activates the prolyl and lysyl hydroxylases that stabilize the collagen triple helix. Its inclusion alongside collagen has a sound and well-established biochemical rationale. Vitamin E is a lipid-soluble antioxidant with a described biochemical interaction with Vitamin C (regenerating oxidized ascorbate). Neither Vitamin C nor Vitamin E is cited here on the basis of independent beauty-outcome RCT evidence at the doses provided in this formula; they are included based on their established nutritional roles.

Known Limitations in the Evidence Base

• The combination-formula RCT (PMID: 38495912) was conducted by authors affiliated with the commercial sponsor; results cannot be attributed to Codeage® Biotin Marine Collagen
• The larger oral HA RCT (PMID: 38009035) included authors affiliated with Bloomage Biotech Co., Ltd.; interpret within that context
• The oral HA meta-analysis (PMID: 40911749) noted limited sample sizes and heterogeneity; larger trials are needed
• Marine collagen RCTs used different proprietary preparations at varying doses; results are not directly transferable to this product
• The Lee et al. fish collagen study (PMID: 38854476) was industry-funded; interpret within that context
• Biotin supplementation for hair growth in non-deficient individuals is not supported by high-quality RCT evidence; evidence for brittle nails is preliminary
• No independent beauty-outcome RCT evidence is cited for Vitamin C or Vitamin E at the doses in this formula
• No trial has tested this specific five-ingredient Codeage formulation

Safety & Drug Interactions

• Allergens: Contains fish-derived marine collagen. Not suitable for individuals with fish or seafood allergies.
• Biotin lab interference: High-dose biotin (10,000 mcg) can interfere with immunoassay-based laboratory tests, including thyroid function tests, troponin, and hormone panels. Inform your healthcare provider and any laboratory before bloodwork.
• Drug interactions: Certain anticonvulsants (e.g., valproate, carbamazepine) and prolonged antibiotic use can deplete biotin. No clinically significant drug interactions are established for collagen peptides or oral HA at these doses.
• Vitamin C: At high supplemental doses, Vitamin C may increase urinary oxalate excretion; individuals with a history of kidney stones should consult their pharmacist or physician.
• Generally well-tolerated: No significant adverse effects reported across the individual ingredient trials cited above.

About Codeage® Biotin Marine Collagen

Codeage® Wild-Caught Marine Collagen with Biotin 10,000 mcg provides marine collagen peptides (Types 1 & 3) from wild-caught fish, hyaluronic acid, biotin, Vitamin C, and Vitamin E in a single capsule (120 capsules per container). Clinical results from the studies reviewed in this article — whether individual ingredient trials or the combination-formula RCT — should not be assumed to apply directly to this finished product.

Who Should Consider This Formula?

• Adults seeking a single-capsule format combining marine collagen, hyaluronic acid, and biotin, with the understanding that no trial has specifically tested this Codeage formulation
• Individuals with brittle nails, where biotin has preliminary supportive evidence
• Those who prefer a marine- over bovine-derived collagen source
• Not appropriate for: individuals with fish or seafood allergies; individuals anticipating laboratory bloodwork should consult their provider about high-dose biotin interference

Pharmacist’s Interpretation

As a PharmD, I discuss this formula as a well-constructed multi-ingredient product where the human evidence ranges from strong (marine collagen for skin hydration and elasticity; oral HA for hydration and wrinkles) to preliminary (biotin for brittle nails) to unsupported for specific claims (biotin for hair growth in non-deficient individuals). The most directly relevant evidence is a placebo-controlled RCT of a five-ingredient combination with the same ingredient categories as this product — but all study authors were affiliated with the commercial sponsor, and Skin Radiance Collagen is not Codeage® Biotin Marine Collagen. The HA meta-analysis is supportive but limited by sample size and heterogeneity. Vitamin C is biochemically essential for collagen synthesis; its inclusion has sound rationale that does not require a separate outcome RCT. I do not represent this article as proof that this product produces the outcomes reported in any cited study.

Frequently Asked Questions

Q: Has a combination like this ever been clinically tested?
A: Yes — a placebo-controlled trial (PMID: 38495912; Trehan et al., 2024) tested a supplement (Skin Radiance Collagen) containing the same five principal ingredient categories and reported improvements in selected skin and hair outcomes at 56 days. However, all study authors were affiliated with the product’s commercial sponsor, and the formulation is different from Codeage® Biotin Marine Collagen. These results cannot be attributed to this product.

Q: Does biotin actually grow hair?
A: Current high-quality evidence does not support biotin supplementation for hair growth in non-deficient individuals. A 2024 systematic review (PMID: 39148962) found that the best-quality RCT showed no significant difference between biotin and placebo for hair growth.

Q: Does biotin help nails?
A: Evidence for biotin in brittle nail syndrome is more favorable — reports of improved nail firmness and thickness have been published — though the evidence base still requires larger controlled trials.

Q: Why is Vitamin C included?
A: Vitamin C is a required enzymatic cofactor for collagen synthesis. Without it, the enzymes that cross-link and stabilize collagen fibers cannot function. Its inclusion alongside collagen has established biochemical rationale, though most collagen trials were conducted without supplemental Vitamin C.

Q: Can I take this if I have a fish allergy?
A: No. This product contains fish-derived marine collagen and is contraindicated in individuals with fish or seafood allergies. Please consult your pharmacist for an alternative.

Q: Will this interfere with my lab tests?
A: High-dose biotin (10,000 mcg) can interfere with immunoassay-based laboratory tests including thyroid function panels, troponin, and hormone assays. Always inform your healthcare provider and laboratory if you are taking high-dose biotin before any bloodwork.

Related Clinical Insights Articles

• Codeage® Wild-Caught Marine Collagen Peptides: Types 1 & 3 Guide →
• Collagen and Gut Health: The Leaky Gut Connection →
• Ancient Nutrition Multi Collagen: Pharmacist’s Guide to Multi-Type Collagen →

Selected Key Studies

1. HUMAN RCT Trehan A, Anand R, Chaudhary G, Garg H, Verma MK. Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects. Clin Cosmet Investig Dermatol. 2024;17:581–591. PMID: 38495912.
   n=40 women aged 38–50; combination formula (collagen + HA + biotin + Vitamin C + Vitamin E) vs. placebo for 56 days; statistically significant improvements in selected skin outcomes (wrinkle depth, fine lines, hydration, texture) and reduced hair fall. Evidence-quality note: All five authors were affiliated with Bright Lifecare Pvt. Ltd., the commercial entity associated with the intervention; the paper states no conflicts of interest, but this commercial affiliation should be considered when interpreting results. Skin Radiance Collagen ≠ Codeage® Biotin Marine Collagen; results cannot be attributed to this product.
2. HUMAN RCT Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825–834. PMID: 32799362.
   n=50 women aged 45–60; Vinh Wellness Collagen 10 g/day vs. placebo for 12 weeks; 35% within-group wrinkle reduction; greater between-group reduction vs. placebo on one side of the face; age-subgroup elasticity improvements. Marine-derived; not this product.
3. HUMAN RCT Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10(7):826. PMID: 29949889.
   n=64; fish collagen peptides 1,000 mg/day vs. placebo for 12 weeks; significant hydration (weeks 6 & 12), wrinkle (week 12), and elasticity improvements. Fish-derived; not this product.
4. HUMAN RCT Lee JS, Yoon YC, Kim JM, Kim YH, Kang YH, Shin YC. Liquid collagen from freshwater fish skin ameliorates hydration, roughness and elasticity in photo-aged skin: a randomized, controlled, clinical study. Nutr Res Pract. 2024;18(3):357–371. PMID: 38854476.
   n=85 randomized (78 completed); ages 35–60; Pangasius fish skin collagen 1,000 mg/day for 12 weeks; significant hydration, roughness, and elasticity improvements. Industry-funded. Fish-derived; not this product.
5. HUMAN RCT Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. PMID: 34203487.
   n=40; ages 35–64; oral HA 120 mg/day for 12 weeks; significant improvements in wrinkles, stratum corneum water content, and skin elasticity vs. placebo. Specific oral HA preparation; not this product.
6. HUMAN RCT Gao et al. Oral hyaluronic acid supplementation for skin hydration: randomized double-blind study. PMID: 38009035.
   n=129 women; randomized, double-blind; oral HA 100 mg/day and 200 mg/day; significant improvements in skin hydration across age groups and skin types; additional skin tone and epidermal-thickness findings. Evidence-quality note: Several authors were affiliated with Bloomage Biotech Co., Ltd., a commercial HA manufacturer; interpret within that context. Specific oral HA preparation; not this product.
7. SYSTEMATIC REVIEW / META-ANALYSIS Meta-analysis of oral hyaluronic acid supplementation for skin outcomes. PMID: 40911749.
   7 RCTs included; statistically significant improvements in skin hydration, elasticity, and wrinkle depth with oral HA supplementation. The authors noted limited sample sizes and heterogeneity across included trials and called for larger, more robust studies.
8. PRELIMINARY Lipner SR, Scher RK. Biotin for the treatment of nail disease: what is the evidence? J Dermatolog Treat. 2018;29(4):411–414. PMID: 29057689.
   Review of biotin for brittle nail syndrome; reports of improved nail firmness, hardness, and thickness; authors called for larger controlled trials. Evidence is preliminary but more favorable than biotin evidence for hair.
9. CRITICAL APPRAISAL Yelich A, et al. Biotin for Hair Loss: Teasing Out the Evidence. 2024. PMID: 39148962.
   Systematic review; only 3 eligible human studies identified; the highest-quality double-blind placebo-controlled study found no significant difference in hair growth between biotin and placebo. Authors concluded biotin use as a hair supplement is not supported by high-quality evidence.

Reviewed by:

Dai Tran, PharmD, MBA, B.S. • View full bio →

CEO & Lead Pharmacist, Khang Pharmacy • CA/MN/TX Licensed Pharmacist

Khang Pharmacy | 2451 S King Rd., Ste A1, San Jose, CA 95122 | (408) 622-8068 | www.khangpharmacy.com